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Adverse drug events

Adverse drug events (ADE) in the US have an annual direct cost of $3.5B USD

For ambulatory patients, these cause:

  • Over 3.5M office visits
  • 1M emergency department (ED) visits
  • 125 thousand hospital admissions

For patients in ambulatory setting, primary care practitioners are most able to help avoid the direct costs.

In the US, ADEs lead to annual direct cost of $65,631 USD per 1,000 older adults.

Of these, the avoidable costs are estimated as $27,365 USD per 1,000 older adults.


  1. Clinical and economic burden of adverse drug reactions.
  2. The costs of adverse drug events in community hospitals.
  3. Adverse Drug Events in U.S. Adult Ambulatory Medical Care.
  4. The costs associated with adverse drug events among older adults in the ambulatory setting.