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  1. Thiazides best first choice for hypertension, Cochrane 2018.
  2. Beta-blockers should not be used as 1st-line therapy for uncomplicated hypertension in patients >60 years (Canada), unless there are comorbid conditions which benefit from beta- blockers. (Beta-blockers are highly effective agents in patients with other indications (such as post-myocardial infarction for a time limited period, or heart failure with reduced ejection fraction).

    REFERENCES:  Tools for Practice sponsored by the Alberta College of Family Physicians (ACFP)