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Serotonin syndrome

Serotonin syndrome is a consequence of excess serotonin on the CNS and/or peripheral nervous system.

Symptoms include cognitive (such as anxiety, agitation), autonomic (such as sweating and tachycardia), and somatic effects (such as tremor or shivering). These may range from barely perceptible to fatal, so should be considered when these symptoms are present in patients with polypharmacy.


  1. List created by the TaperMD team. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
  2. Drug-Induced Serotonin Syndrome (Medscape)