Taper/Deprescribing Guidelines

Allopurinol
Antipsychotics
Antihyperglycemics
Benzodiazepine Receptor Agonists (aka BZD, BDZ, BZs, BZRA)

Benzodiazepine receptor agonists (BZD, BDZ, BZs), sometimes called “benzos” are a class of drugs are commonly known as minor tranquilizers. Older adults are at an increased risk of both short- and long-term adverse effects.

    • 5-fold higher risk of memory and concentration problems.
    • 4-fold increased risk of daytime fatigue.
    • 2-fold increased risk of falls and fractures (hip, wrist).
    • 2-fold increased risk of having a motor vehicle accident.

Benzos are listed in the Beers List of inappropriate medications for older adults.

*Canadian Deprescribing Network

**Primary Health Tasmania

Biophosphonates
Cholinesterase Inhibitors (ChEIs) and Memantine
First-generation antihistamines
Non-steroidal anti-inflammatory drugs (NSAID)
Sedative-hypnotic medications
Proton Pump Inhibitors

*Canadian Deprescribing Network

**Primary Health Tasmania


Thompson W, Hogel M, Li Y, Thavorn K, O’Donnell D, McCarthy L, Dolovich L Black C, Farrell B. Effect of a proton pump inhibitor deprescribing guideline on drug usage and costs in long-term care. JAMDA, 2016, in press, doi.org/10.1016/j.jamda.2016.04.020.

Boghossian TA, Rashid FJ, Welch V, Rojas-Fernandez C, Moayyedi P, Pottie K, Walsh K, Pizzola L, Thompson W, Farrell B. Deprescribing versus continuation of chronic proton pump inhibitor use in adults (protocol). Cochrane Database Syst Rev, 2015; Issue 11, article number CD011969.