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H2 Blockers

H2 receptor antagonists (Cimetidine, Famotidine, Nizatidine, and Ranitidine) should be avoided in older adults due to the potential risk of causing or exacerbating delirium and other neuropsychiatric disorders.

Resource Links

Cantu TG, Korek JS. (1991). Central nervous system reactions to histamine-2 receptor blockers. Ann Intern Med. 114(12): 1027-34.