Proton Pump Inhibitors

Taper Guide

The Deprescribing Guidelines for the Elderly project has developed an evidence-based guideline to support clinicians in safely reducing or stopping proton pump inhibitors, a class of drugs that reduce acid production in the stomach. The team has also developed a deprescribing algorithm to help clinicians decide when and how to reduce proton pump inhibitors safely and how to monitor effect. See links in the section below.

Resource Links

Bruyere Research Institute at


Primary Health Tasmania

The following links are to the resources available at the Canadian Deprescribing Network web site.

  1. Proton Pump Inhibitor evidence-based deprescribing guideline.
  2. Proton Pump Inhibitor deprescribing algorithm.
  3. Whiteboard video on using the Proton Pump Inhibitor deprescribing algorithm.
  4. Patient handout on Proton Pump Inhibitors.
  5. Proton Pump Inhibitor (PPI) Patient Decision Aid
  1. Thompson W, Hogel M, Li Y, Thavorn K, O’Donnell D, McCarthy L, Dolovich L Black C, Farrell B. Effect of a proton pump inhibitor deprescribing guideline on drug usage and costs in long-term careJAMDA, 2016, in press,
  2. Boghossian TA, Rashid FJ, Welch V, Rojas-Fernandez C, Moayyedi P, Pottie K, Walsh K, Pizzola L, Thompson W, Farrell B. Deprescribing versus continuation of chronic proton pump inhibitor use in adults (protocol)Cochrane Database Syst Rev, 2015; Issue 11, article number CD011969.