Estrogens

Tapering Guidance

If used daily for more than 1-2 months

Reduce dose by a maximum of 25% every week initially (i.e. week 1 75%-50%-25%) and this can be extended if needed
If intolerable withdrawal symptoms occur (usually 1-3 days after a dose change), go back to the previously tolerated dose until symptoms resolve and plan for a more gradual taper with the patient
Dose reduction may need to slow down as one gets to smaller doses (i.e. 25% of the original dose)
Overall, the rate of discontinuation needs to be controlled by the person taking the medication

Withdrawal Symptoms and Monitoring Guidance