Taper Guide. Opioids and opiates, in general, respond to rapid tapering covered by the use of clonidine or lofexidine. Both these drugs act on adrenergic receptors to damp down locus coeruleus hyperactivity. Clonidine also acts on imidazoline receptors which may be significant.
Initial Withdrawal Symptoms. Restlessness, runny nose, goose flesh, sweating, muscle cramps, insomnia, nausea, diarrhea, pain, and dilation of the pupils.
Enduring Withdrawal Symptoms. Depression, anxiety, and craving.