The information below is intended as a reference only, and should not be taken as medical advice. If you have questions about your medications, consult your pharmacist, doctor, nurse, or other healthcare professional.
Opioids and opiates, in general, respond to rapid tapering covered by the use of clonidine or lofexidine. Both these drugs act on adrenergic receptors to damp down locus coeruleus hyperactivity. Clonidine also acts on imidazoline receptors which may be significant.
Initial Withdrawal Symptoms
Restlessness, runny nose, goose flesh, sweating, muscle cramps, insomnia, nausea, diarrhea, pain, and dilation of the pupils.
Enduring Withdrawal Symptoms
Depression, anxiety, and craving.