Statins

There is no evidence of benefit for all cause mortality for statins used for primary prevention in older adults. (see Mangin BMJ)

This was confirmed in the more recent ALLHAT analysis, in which no benefit was found when pravastatin was given for primary prevention to older adults with moderate hyperlipidemia and hypertension, and a nonsignificant direction toward increased all-cause mortality with pravastatin was observed among adults 75 years and older.

Reference(s):

  1. Cholesterol drugs for people 75 and older — When you need them—and when you don’t [© 2017 Consumer Reports. Developed in cooperation with AMDA—The Society for Post-Acute and Long-Term Care Medicine].
  2. Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults The ALLHAT-LLT Randomized Clinical Trial [Jama Internal Medicine].
  3. Yes, Statins Work. But Who Should Take Them? [Medshadow]
  4. Preventive health care in elderly people needs rethinking [BMJ Dee Mangin, Kieran Sweeney, and Iona Heath]
  5. Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults
  6. Statins in primary cardiovascular prevention. Little benefit, documented harms and many uncertainties regarding long-term use [Prescrire International July 2018]